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The picture is complicated by the presence of additional MDHA- and DHA-reducing systems, in addition to the enzymes encoded by the genes shown in Table 1

For example, the deletion of the core clock gene Bmal1 in the mouse brain led to astrocyte activation - an established marker of brain and neuronal injury - as well as synaptic degeneration [179]

How these hybrid networks are wired and environmentally regulated in wild populations remains a key question

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NNT activity contributes to 45% of the total NADPH in mitochondrial pool, indicating a significant role of NNT for NADPH pool maintenance, 111 and NADPH obtained by NNT is also used for the reductive carboxylation of -KG to isocitrate mediated by IDH2