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Loss of heterozygosity of the NF1 gene in Schwann cells has been shown to be the necessary event for the development of discrete neurofibromas.8 Furthermore, neurofibromin-deficient Schwann cells secrete a substance which stimulates mast cell migration which, in turn, stimulates production of extracellular matrix and angiogenesis.9 Astrocytes lacking NF1 expression cannot form optic nerve gliomas on their own