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2014;5(5):e1249

Drug-Drug Interactions and Polypharmacy: Many oral chemotherapy agents are substrates, inhibitors, or inducers of cytochrome P450 enzymes , particularly CYP3A4 , which plays a central role in hepatic drug metabolism

To investigate whether the ROS is generated by the host or the pathogen, we inhibited Bd growth by increasing the temperature beyond the thermal optimum of Bd , and/or supplemented the cells with cysteine (a glutathione precursor) with the hypothesis that if ROS was pathogen generated it should decrease under these conditions

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