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The ELEVATE-TN study compared acalabrutinib obinutuzumab (AcalaO) with chlorambucil + obinutuzumab (CBL+O) in previously untreated CLL patients.49 Median follow-up was 28.3 months with PFS rates of 93 %, 87 % and 47 % for Acala+O, Acala monotherapy and CBL+O, respectively

Therefore, oxidative cell death mechanisms offer the potential to selectively target and eliminate cancer cells while sparing healthy tissues, thereby minimizing the adverse effects commonly associated with traditional therapies