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A deficiency of Zn in IBD could arise from multiple factors, most notably dietary deficiency, which may result from dietary insufficiency, malabsorption due to other dietary factors (e.g., phytates), or genetic malabsorption

This increases blood flow, possibly helping with RLS

A relationship between long-term metformin use and vitamin B12 deficiency has been long discussed, and many readers will have come across this in clinical practice

The Diabetes Prevention Program was a large, long-term study enrolling people with pre-diabetes, with one arm using metformin

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