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As mentioned, some clinics have already started applying this NNMT inhibitor to humans, even though the FDA has made no ruling on its safety, making human trials paramount

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Garrigues, E

Many of these relate to tissue remodeling, antioxidant response, and anti-inflammatory pathways

Stack the two gaps together and the picture for the conventional protocol is unflattering: approximately one-fifteenth of the studied dose, delivered by a route that animal data suggest requires several-fold more peptide, targeting a compound whose dose-response may not be monotonic anyway