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Although CD8 + T cells sensitize target cancer cells to ferroptosis 225 , in syngeneic tumour models, it was found that ferroptosis-blocking antioxidant treatment improves responses to immunotherapy by preventing the immunosuppressive death of tumour-associated neutrophils 226

This architecture creates an extraordinarily high binding affinity (pK = 16.44), roughly 10 million times stronger than other tripeptides and comparable to albumins copper binding

Experimental and theoretical studies determined the mechanism of antioxidant action

doi: 10.1080/1028415X.2022.2077031

10.1016/j.aca.2021.338578 141 HuangQ.-Y.ChenS.-R.ChenJ.-M.ShiQ.-Y.LinS