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Diet also affects the composition of the gut microbiota, but no specific dietary components have as yet been identified that can impact the risk of development of AS

Ito K, Yano T, Hagiwara K, Ozasa H, Horikawa S

The association of low selenium and renal insufficiency with coronary heart disease and all-cause mortality: NHANES III follow-up study

However, it was demonstrated that extracellular proteins can be taken up by cells through macropinocytosis, a process that involves a nonselective engulfment of the extracellular fluid phase, which gives rise to giant vesicles termed macropinosomes (Kerr & Teasdale, 2009)

Other studies demonstrated that G protein-coupled receptor 35 (GPR35) is also a receptor for kynurenic acid, which inhibits pro-inflammatory cytokines (e.g