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For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)

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PMID: 1318377 Ferreira S, Crumb WJ Jr, Carlton CG, Clarkson CW (2001): Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel

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