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It is naturally produced in the liver and plays a critical role in various bodily processes, including tissue building and repair, immune system functioning, and the detoxification of chemicals and pollutants

These studies reveal that LBP participates in spermatogenesis, testicular structural protection, and endocrine regulation through multiple pathways (Table 2), thereby improving sperm quality and alleviating reproductive dysfunctions caused by various etiologies

Therefore, defining the metabolic profiles of these cellular subpopulations and their specific roles in tumorigenesis and progression constitutes a fundamental prerequisite for precision therapeutic intervention