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As methionine is the only precursor of cysteine in a cysteine-free diet, and cysteine is one of the three amino acids comprising glutathione, MR might logically be expected to reduce, rather than increase, glutathione levels

doi: 10.1093/hmg/ddaa183 193

Because the mitochondrial leader peptide is cleaved off after import into mitochondria, c-GPx4 and m-GPx4 cannot be distinguished on the protein level anymore

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The people who experience them are nearly always making the same mistake: too much, too soon