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Diagnosis of pulmonary embolism during pregnancy: a multicenter prospective management outcome study

(11) Although large doses may have side effects in some groups, generally doses up to 2,000 mcg/day are considered safe in case of deficiency

In a clinical trial half of patients receiving a 200mg dose followed by 100mg dose 2 weeks later were experiencing a clinical response to the drug at 6 weeks, with 18% in clinical remission

Long-term human safety data beyond 12 weeks doesnt exist yet, so protocols requiring extended dosing should implement appropriate monitoring

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