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Furthermore, inducing ferroptosis by inhibiting the cellular antioxidant system presents a potential therapeutic strategy for OS, as various anticancer agents exert their effects by targeting antioxidant system-related proteins such as GPX4 ( 3 Ferroptosis in bone microenvironment The bone microenvironment encompasses the local setting where bone tissue resides, comprising key cellular components such as osteoblasts, osteoclasts, and osteocytes within the tissue, along with adipocytes, vascular networks, immune cells, and an abundance of bone marrow and extracellular matrix (81)

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doi: 10.1016/j.jaut.2023.103030 88 ShenDLiuKWangHWangH

MSM is likely safe to take by mouth for up to six months

doi: 10.1073/pnas.1215761109 23 KangAYeGAfkhamiSAleithanFSinghKDvorkin-GhevaAet al