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Heisterkamp, N., Groffen, J., Warburton, D

The absence of functional assessments (e.g., epididymal sperm count, motility, viability, and chromatin integrity) limits interpretation of the findings

To further confirm that the ferroptosis resistance of 4-OI was dependent on Nrf2, the siRNA against Nrf2 was constructed and successfully reduced Nrf2 levels in THP-1 cells (Fig