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Measurements Blood samples were obtained from all patients at baseline period (M0) and the test points during the study (1 month (M1), 3 months (3 M), 6months (6 M), 12 months (12 M)), before and after a session of HD

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GTP turnover was then started by adding GTP (5 M) and GDP (10 M), and the amount of remaining GTP was assessed after 10 min incubation at 15 C using the GTPase-Glo assay (Promega)

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This can be done orally, topically, intravenously, intranasally, or in nebulised form