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[139] demonstrated that all-trans retinoic acid suppressed PI3K/Akt activity and increased the GSK-3-dependent degradation of phosphorylated -catenin, resulting in the differentiation of hepatic CSCs and increasing their sensitivity to docetaxel

10.1038/icb.2012.33 197

Ample intake of vitamin D may reduce the risk of colorectal and breast Recommended daily intakes for vitamin D (g) cancer.12 Prevention of deficiency Toxicity UK RNI (1991) USA DRI (1997) There is a wide range of susceptibilty to the toxicity of vitamin D2