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Innate immune cells, including microglia, effectively integrate and rapidly respond to environmental cues

For example: Around a strained Achilles tendon Near a rotator cuff injury SubQ in the abdomen for systemic inflammation Localized delivery may enhance growth factor expression and collagen synthesis directly at the site of damage

Diabetes and trajectories of estimated glomerular filtration rate: a prospective cohort analysis of the atherosclerosis risk in communities study

That's the typical pathway for this demographic: topical exposure first, then discovery of systemic protocols, then a clinical consultation to make sense of the gap between the two

The biggest mistake I see is stopping the protocol as soon as symptoms improve