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It has an hepatic metabolism, mainly because of the glucuro-conjugation of the molecule, with the formation of inactive metabolites

This leads to damage to tissue cells, including vascular ECs (Incalza et al., 2018), adipocytes (Furukawa et al., 2004), and pancreatic -cells (Gerber and Rutter, 2017)

Acknowledgements This work was supported by the National Natural Science Foundation of China [grant numbers 82125037], Science Foundation for Distinguished Young Scholars of Jiangsu province [grant number BK20231528], Key R&D Program of Jiangsu Province [grant number BE2022815], Jiangsu Provincial Medical Innovation Center [grant number CXZX202225], Young Elite Scientists Sponsorship Program of the China Association for Science and Technology [grant number 2021-QNRC2-B17], and 333 high-level talents project of Jiangsu Province for Yang Yang [grant number BRA202202]

Clinical trials demonstrated meaningful reductions in body weight and fat mass, with particular effectiveness for visceral adipose tissue

This ensures that your ruminants receive all the necessary nutrients for optimal health without any risk of over-supplementation