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In addition, the role of perturbations in cardiac substrate metabolism inclusive of epigenetic alterations (Zhao et al., 2023

By helping stabilize excitatory signaling and reduce brain sensitization, it targets a mechanism directly linked to tinnitus loudness and reactivity

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doi: 10.1128/IAI.73.4.2351-2359.2005

Several age-related factors cause this high prevalence: Atrophic gastritis (affects 8-9% of adults over 65) Decreased production of intrinsic factor Reduced stomach acid secretion Helicobacter pylori infection Medication interactions (especially with proton pump inhibitors) Untreated B12 deficiency can have serious effects on physical and neurological functions