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He took 2 year old mice, gave them this special form of B3 in their water, and a WEEK later checked their cellular age markers: They now had the cellular age markers of 6 month old mice

175-178 Nevertheless, niacin has demonstrated antithrombotic effects, including inhibiting a coagulation cascade enzyme called factor VII, reducing fibrinogen levels, decreasing expression of tissue factor, suppressing plasminogen activator inhibitor-1 (an enzyme that inhibits fibrinolysis), lowering blood viscosity, and decreasing platelet aggregation

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Then, through clinical use and just experience, we learned that, "Oh, I can use doxycycline or a Z-Pak, azithromycin or whatever it is for a variety of bacterial infections that extend well beyond just what it's approved for