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However, only one of the two major cellular ROS degrading regulators, SoxR (PP_2060 log 2 -FC 1.1), was found to be marginally up-regulated

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713,714 Paradoxically, NRF2 also prevents oxidative stress and apoptosis in HBV-infected cells by inducing ALR expression, thereby supporting viral replication

Metabolite analysis The concentration of 5-MTHF and THF in brain tissue were measured by LC-MS/MS as previously described 42,43 Samples were prepared to measure monoglutamate forms of folate intermediates following a deconjugation protocol as previously described 42