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Tips for working with eflornithine Though generally well tolerated, localized burning and stinging has been noted with topical application of eflornithine

[PubMed: 10865843] 9

A double-blind randomized controlled trial testing an antioxidant combination treatment (vitamin E, vitamin C, and -lipoic acid) in Alzheimers disease patients reported that this treatment was associated with accelerated cognitive decline as measured by the MMSE, despite a decrease in the level of oxidative stress (F2-isoprostane) in the cerebral spinal fluid (CSF) (19)

Despite promising preclinical data, the critical transition of Cu-MOFs and similar nanoplatforms to clinical application faces hurdles, including scalable fabrication, long-term biodistribution studies, and a comprehensive understanding of potential off-target cuproptosis