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However, it is primarily used off-label for age-related cataracts and its clinical efficacy remains a subject of debate due to inconsistent and controversial findings from clinical studies

In the specific in vitro assay measuring synaptogenesis promotion, Dihexa showed activity at picomolar concentrations far lower than concentrations needed for BDNF or other neurotrophic factors to produce comparable effects

This reduces its potency over time, often requiring costly, specialized packaging to maintain efficacy

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