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For instance, taurine-conjugated bile acids stimulate the growth of IECs by activating Src, the epidermal growth factor receptor (EGFR), and ERK pathways

This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility ( Figure 3 Besides glutamine, arginine metabolism also plays a complex role in ferroptosis regulation