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Subramaniyam, D

Whether partial TCA cycle reverse activity due to the large accumulation of fumarate, leading to SDH reversal and fumarate reduction to succinate, as it has been observed in ischaemia [36], or cells treated with mitochondrial inhibitors [37], occurs in Fh -1 deficient cells has not been reported

Although crosstalk between BH 4 /CoQ 10 and xCT/GPX4 pathways, which reduces lipid peroxidation and ferroptosis, has been reported, further studies are needed to investigate the anti-ferroptotic properties of the BH 4 /CoQ 10 system

However, p53 deletion-induced non-small cell lung carcinoma (NSCLC) is sensitive to the disruption of BCAT1/2 because the high expression of BCAA catabolic enzymes leads to active use of BCAAs (Mayers et al., 2016)

Alternatively, the up-regulation of ddh may be due to direct inhibition of the enzyme by DSF and/or DDTC