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In terms of estimated impacts to the Medicare program, we believe that the proposals discussed in section III.B.2 of this final rule will have no impact on Medicare spending

doi: 10.4103/1673-5374.335825 48

doi: 10.15226/2575-6303/2/1/00113 29 LebelYMiloTBarAMayoAAlonU

However, the amount of sample obtained from a given patient is always extremely limited, which is even more critical for diseases like ALS, a rare and rapidly progressing fatal orphan disease (ORPHA:803), limiting the number of patient samples obtained for analysis