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Although it does not affect physical health, it can disrupt periorbital esthetics, revealing a tired and aged appearance, thereby affecting the patients quality of life (Citation13)

300,301 Recent findings suggest that exposure to certain environmental factors such as pesticides can augment astrocyte proinflammatory signalling and thereby promote CNS autoimmune inflammation

doi: 10.1177/074873001129001980 70 ZhangLZhangZWangJLvDZhuTWangFet al

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196,283,284,285,286,287,288,289 Case reports from Italy have shown that patients with a history of psoriasis and previous treatment with IL-17A antagonists including secukinumab and ixekizumab showed relatively mild COVID-19 symptoms or were even asymptomatic