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ESMO World Congress on GI Cancer 2017 28(suppl_3), 2017

Caffeine metabolism: A matter of individual biology Variations in genes such as CYP1A2 and ADORA2A explain much of caffeines interindividual variability., CYP1A2 determines how quickly caffeine is cleared from the bloodstream, while ADORA2A influences sensitivity to adenosine receptor blockade in the brain