glutathione reductase deficiency anemia Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders Oxidative stress, eryptosis and anemia:

doi: 10.3389/fnut.2022.1007816 Received 31 July 2022 Accepted 12 October 2022 Published 01 November 2022 Volume 9 - 2022 Edited by Yannan Jin, De Montfort University, United Kingdom Reviewed by Mostafa Waly, Sultan Qaboos University, Oman

Powerful Detoxification The liver relies heavily on glutathione to filter toxins, heavy metals, alcohol, and pollutants from the body

Oxidants can stimulate many upstream kinases in signaling pathway cascades, and yet inhibit transcription factors AP-1 and NFB

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However, the traditional view that NADPH is required strictly for the glutathione peroxidase and catalase systems need to be revised with new insights in the form of another major player in RBC antioxidant defense, peroxiredoxin 2 (Prdx2)