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The study outlines the complex interplay between nutritional control and the gut environment on host metabolism driven by nicotine treatment, however, further studies are required to understand the precise regulatory mechanisms of the gut microbiome and its metabolites, in response to nicotine exposure

Herein, nicotines effect on its primary targets includes epithelial, endothelial, fibroblast, and immune cells like DCs, macrophages, T, and B cells are covered (Fig