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Total SADs were obtained from summing up the number of current and former smokers at each age multiplied by their relative risk attributable to smoking

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(3) If the 60th calendar day described in paragraphs (d)(1) and (2) of this section is a weekend or a Federal holiday, then the timeframe is extended until the end of the next business day

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These factors interact in complex ways, increasing the likelihood of developing substance use disorders