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3.2.3 Changes in intestinal microbiota In a healthy intestinal tract, the microbiota and the gut immune system interact to maintain a homeostatic equilibrium

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Factors like chronic stress, illness, or pollution can overwhelm the body's natural production

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018

It is believed to influence cellular signaling pathways, including the activation of mechanisms critical for tissue repair and regeneration