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Description

Ablation of Ferroptosis Regulator Glutathione Peroxidase 4 in Forebrain Neurons Promotes Cognitive Impairment and Neurodegeneration

doi: 10.1016/j.freeradbiomed.2017.08.009

AKT regulates cell survival, growth, and proliferation through the phosphorylation and inhibition of several downstream targets, such as the metabolic regulator (glycogen synthase kinase-3) GSK3, transcription factor (forkhead box O1/3a) FOXO1/3a, and the mTORC1 inhibitor (tuberous sclerosis complex) TSC2 [5]