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To test the association between DNAm and the RI, we employed a robust linear model that adjusted for diagnosis, which ensures that our findings are applicable for both diagnostic groups

The VEGF-dependent pathway raises the expression of vascular endothelial growth factor (VEGF) via MAPK (Mitogen-activated protein kinases), and the phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI3K/Akt/mTOR), PTEN (phosphatase and tensin homolog) signaling pathway via p70S6K1 (ribosomal protein S6 kinase B1) and HIF-1 (Hypoxia-inducible factor1-alpha), that releases different growth factors, cytokines, and undergo the upregulation of MMPs which leads to angiogenesis

Depending on their pathophysiological condition and cellular origin, EVs can have a very diverse composition [106]

No changes were seen in the low-dose group (gray bars)

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